T.J. Williams scored 20 points, Donnell Gresham Jr. added 13 points for Northeastern (2-0) and Alex Murphy had nine points and 15 rebounds.
The UConn Huskies had a chance to tie the game at the end when Alterique Gilbert stole the ball as Northeastern was trying to run out the clock. But his 3-pointer hit the rim.
Northeastern led most of the way and was up 35-31 at halftime.
UConn went on a 9-1 run to open the second half to take the lead, but Northeastern responded with a 10-2 run of their own.
A fast-break dunk by Murphy gave Northeastern its largest lead of the second half at 61-54 with just under 4 minutes left.
Larrier's off-balance runner in the lane cut the lead to 64-61 with 1:07 left and the Huskies forced a turnover to get the ball back. But Larrier missed two 3-pointers before Gilbert's play at the end.
Northeastern outrebounded UConn 47-38. They also hit 9 of 28 from 3-point range while holding Connecticut to just 5 of 21 shots from behind the arc.
UConn: The Connecticut Huskies head west and then head further west. UConn plays its first road game against Loyola Marymount in Kevin Ollie's hometown of Los Angeles before traveling to Hawaii for the Maui Invitational, where Oklahoma State will be the opening round opponent on Nov. 21.